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KMID : 0363220070450040327
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Korean Journal of Dermatology
2007 Volume.45 No. 4 p.327 ~ p.331
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Expression of Protoporphyrin Ⅸ induced by Liposome δ-5-aminolevulinic Acid in Cultured Sebocytes and Hair Organs
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Lee Weon-Ju
Lee Seok-Jong
Kim Do-Won
Park Kyung-Duck
Kim Mun-Kyu
Kim Jeong-Chul
Sohn Mi-Yeung
Han In-Sook
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Abstract
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Background: Photodynamic therapy with topical delta-5-aminolevulinic acid (ALA) has been introduced for effective treatment of facial acne. Topical routes for ALA have been explored via a photosensitizer delivery system.
Objective: We performed this study to evaluate absorption of liposome ALA (Lipo-ALA) into the sebocytes of cultured sebaceous glands and hair organs.
Methods: We cultured KGM sebocytes that were derived from human sebaceous glands. In addition, we cultured William E media pilosebaceous hair units that were isolated from the occipital scalp. Lipo-ALA (10 microgram/ml) and ALA (10 microgram/ml) were added to the 1 ml KGM containing sebocytes for 24 hours and the 1 ml William E media containing pilosebaceous hair units for 6, 24, 48 and 72 hours, respectively.
Results: Absorption of Lipo-ALA into the sebocytes of cultured sebaceous gland and hair organs was higher than that of ALA.
Conclusion: Lipo-ALA may be considered as an effective photosensitizer in photodynamic therapy for facial acne.
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KEYWORD
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Acne, ALA, Liposome δ-5-aminolevulinic Acid, Photodynamic therapy
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